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Makerere’s Assoc. Prof. Annettee Nakimuli wins US$1M grant for Maternal Health Research

This is a major research project because GOS is a major killer in sub-Saharan Africa accounting for 60% of the deaths of mothers.

Associate Professor Annettee Nakimuli, Dean – School of Medicine has been awarded a US$1M grant for Maternal Health Research from the Gates Foundation Calestous Juma Science Leadership Fellowship.

The five-year grant, entitled “Enhancing prediction of adverse pregnancy outcomes in Africa through partnerships and innovation” will focus on Great Obstetrical Syndromes (GOS), such as pre-eclampsia, preterm birth, stillbirth, intrauterine growth restriction; to help develop context-relevant interventions for prevention and treatment.

This is a major research project because GOS is a major killer in sub-Saharan Africa accounting for 60% of the deaths of mothers. Maternal mortality in Uganda remains high in the region at 336/100,000 live births which is approximately a 14-seater bus of women dying per day.

Dr. Nakimuli, a graduate of Makerere University College of Health Sciences, is an internationally-recognized research leader in maternal health for Africa. Her work can be traced back to 2006 when she was appointed an Assistant Lecturer in the Department of Obstetrics and Gynaecology, Faculty of Medicine, Makerere University.

She then enrolled for Ph.D. in 2009 to investigate how KIR and HLA-C genetic variants contributed to the pre-eclamptic risk in Ugandans which was the first genetic case-control study of pre-eclampsia in indigenous Africans – despite African ancestry being a predisposing factor to pre-eclampsia. She concluded that African women are at greater risk of preeclampsia than other racial groups.

She will establish a cohort study of 4000 healthy pregnant women at Mulago and Kawempe Hospitals in Kampala, Uganda will be conducted where detailed clinical, biological, and demographic information from mothers throughout pregnancy and from their babies at the time of birth will be collected.

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Dr. Nakimuli Annettee has researched extensively on maternal health, mentored young scientists, and supervised many masters and PhD students.

The study has the potential to shed light on determinants, mechanisms, and solutions for the excess burden of maternal and perinatal morbidity and mortality in SSA and for women with African ancestry elsewhere in the world. This study builds on Dr. Nakimuli’s project where she is investigating predictors of pre-eclampsia in a cohort of 1,500 healthy pregnant women; supported by the Future Leaders–African Independent Research (FLAIR) fellowship project funded by the Royal Society through the African Academy of Sciences.

Some of the products from the grant/study include i) the biobank from this research will provide an important resource for future research studies. ii) build capacity for African scientists to solve problems of the Africa continent other than dependence on foreign experts iii) develop regional partnerships iv) multidisciplinary research where scientists from various areas work together.

Dr. Nakimuli expressed her appreciation for the opportunity given to her by the Gates Foundation to undertake the study as well as the support from colleagues at the College of Health Sciences and Makerere University. She also highlighted the work accomplished through a partnership with scientists at the Department of Obstetrics and Gynaecology, University of Cambridge, U.K headed by Prof. Gordon Smith.

Source: Makerere University Official Website.

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